Adrian Rollini was a child prodigy on piano; at age four he played a recital at the Waldorf Astoria Hotel (34th sreet and 5th Avenue) in New York. He led his own band at age 14 and began playing with the California Ramblers in the early 1920s. The California Ramblers were one of the most recorded bands of the 1920s. The band also featured Red Nichols, Jimmy and Tommy Dorsey. The California Ramblers played popular tunes of the day with a Jazz influence. While in that band Rollini developed his distinctive style of bass saxophone playing.
He played in Red Nichols' Five Pennies and appeared on many of Red's recording sessions.
He also worked with Frankie Trumbauer and his Orchestra and recorded with Cliff Edwards and Bix Beiderbecke and his Gang. In 1934 he put together some recording sessions that featured Jack Teagarden, Bunny Berigan and Benny Goodman.