Katherine Henderson was born St. Louis, Missouri in 1909. She got her start in show business as a small child working in minstrel shows and on the vaudeville curcuit. Katherine was the niece of Eva Taylor and Clarence Williams and came under their wing when she settled in New York in the early Eva Taylor and substituted for her ocassionally on local radio shows.
She performed in Clarence Williams' musical review "Bottomland" and in several other theatrical shows and revues including "Keep Shuffling". She remained active in show business until 1944 when she moved back to her hometown of St. Louis and got married and had three children.